Lee Lab

How can we extend healthy lives while escaping age-related diseases? For example, by employing comparative and functional genomics, the Lee lab uses a multi-scale and multi-modal AI-enabled approach to explore the circuit and molecular logic of aging and Alzheimer’s Disease (AD) at the whole brain level. Our lab specifically focuses on the predementia phase, with a goal of improving early detection and prevention, and developing cell- and circuit-specific precision medicine at predementia stages beyond managing symptoms as is now mainly the case at dementia stages. By working across species and models, we hope to understand how to stave off familial and sporadic AD. Toward this goal, the Lee lab aims to understand how the interplay of longevity genes, AD risk genes, environmental factors (e.g., pathogens), and lifestyle choices (e.g., diets) may contribute to extending a healthy, age-related disease-free life.